Description
Glutathione is the primary intracellular antioxidant, central to phase II liver detoxification, inflammatory modulation, and cellular redox balance. NAC is the rate-limiting precursor — oral glutathione supplementation has poor bioavailability; NAC delivers the cysteine substrate that allows cells to synthesize glutathione where it’s actually needed. At 700mg per capsule, this is a clinical dose consistent with the ranges used in published research rather than the token amounts common in multi-ingredient antioxidant blends. I keep this as a standalone formula because the patients who benefit most need NAC specifically, not NAC as a line item in a stack.
In endometriosis, oxidative stress is both a driver and a consequence of the inflammatory environment — a published randomized trial found NAC reduced endometrioma diameter and was comparable to hormone-based management at three months, which is a finding the clinical literature doesn’t discuss enough. In PCOS, RCT data supports NAC for insulin sensitivity and ovulation support at doses in this range. Beyond those two conditions, I reach for it with patients carrying high inflammatory load, anyone supporting liver detoxification, and women post-antibiotic or with disrupted mucosal barrier integrity. One formula, one ingredient, a dose that matches the research.
